Moderate to severe pain, obstet & pre-op analgesia, enhancement of anaesth, basal narcosis w/ phenothiazines.
Dosage/Direction for Use
SC/IM 25-100 mg 4 hrly. Obstet analgesia 50-100 mg every 1-3 hr if necessary. Max: 400 mg in 24 hr. Elderly & debilitated patient Max initial dose: 35 mg inj. Childn 0.5-2 mg/kg single IM dose, repeat if necessary but not >4 hrly. Slow IV 25-50 mg 4 hrly.
Contraindications
History of hypersensitivity or idiosyncratic response. Bronchial asthma, increased intracranial pressure, resp depression, hypotension, acute alcoholism. Concomitant use of MAOI treatment w/in 14 days. Severe hepatic disease. Pregnancy & lactation.
Special Precautions
Decreased resp reserve or receiving other CNS depressant drugs; presence of phenobarb or any other enzyme-inducing agents. Administration during labour; supraventricular tachycardia; head injuries, biliary tract disorders, hypothyroidism, adrenocortical insufficiency, shock, prostatic hypertrophy; cancer or sickle anaemia. Cross-tolerance between narcotic analgesics can occur. May affect ability to drive or operate machinery. Hepatic disease. Renal failure; severe renal impairment. Newborn, premature infants or childn <1 yr. Elderly & debilitated patients.
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